There was a total of approximately $1 million of land and rural real estate for sale in Brule County, South Dakota, recently on Land.com. The total size of all Brule County land and rural real estate for sale was nearly 1,000 acres. Brule County ranks 42nd in the Mount Rushmore State for the combined amount of land currently advertised for sale. Chamberlain featured the most land for sale. Agriculture and farming drives the Brule County economy, with 407 farms recorded in the county during the U.S. Census in 2012. Farming activities in Brule County generate annual revenues of $12 million, most of which is from crops. Brule County is the 38th biggest county (846 square miles) in South Dakota. It's located in the Great Lakes South Dakota region of the state.