A combined around 1,000 acres were listed for sale in Brule County, South Dakota, recently; the overall value of all Brule County farms and ranches for sale was around $5 million. Brule County ranks 31st out of 66 counties in the Mount Rushmore State for the total acreage of land currently advertised for sale. Chamberlain had the most land for sale. Its economy is defined as agricultural, with 407 farms recorded in the county during the most recent U.S. Census. Farming activities in Brule County generate annual revenues of $12 million, most of which is from crops. Brule County is South Dakota's 38th largest county (846 square miles). It's located in the Great Lakes South Dakota region of the state.