The value of land for sale in South Dakota's Brule County recently on Land.com was nearly $5 million. This represents around 1,000 acres of farms, ranches, and rural real estate for sale in Brule County. Brule County ranks 32nd in South Dakota for the total acreage of land currently advertised for sale. Chamberlain had the most land for sale. Its economy is defined as agricultural, with 407 farms recorded in the county during the most recent U.S. Census. Farming activities in Brule County generate annual revenues of $12 million, most of which is from crops. Brule County is the 38th largest county (846 square miles) in South Dakota. It's located in the Great Lakes South Dakota region of the state.