Brule County is in Great Lakes South Dakota. Of the 66 counties in the state, 846-square-mile Brule County ranks 38th by size. The total value of nearly 1,000 acres of residential land recently listed for sale in South Dakota's Brule County was almost $4 million. The average price of residential acreage for sale in Brule County was $442,891. The economy here is principally agricultural. Browse all residential land and rural property for sale in South Dakota to find residential land and properties that suit your lifestyle needs, from existing residential homes and estates to land ready for future residential-property development.