Brule County is in Great Lakes South Dakota. Of the 66 counties in the Coyote State, 846-square-mile Brule County ranks 38th by size. Recent listings of residential land for sale in South Dakota's Brule County totals approximately 1,000 acres and a combined market value of around $3 million. The most common type of land for sale by combined acreage in Brule County is house. The average price of residential acreage for sale in Brule County was $533,872. The economy here is principally agricultural. Browse all residential land and rural property for sale in South Dakota to find residential land and properties that suit your lifestyle needs, from existing residential homes and estates to land ready for future residential-property development.